For those who have survived the minefield of the NFL’s first five weeks, the NFL survivor pool options narrow even further. Besides the teams that have already been used, two more teams will have their bye this week with the Texans and Vikings. Among the SportsLine models biggest favorites to choose from this week are the Packers (-14.5). who are the biggest favorites of the 2025 NFL season versus a Cincinnati team slated to start Joe Flacco. Other large NFL spreads include Broncos (-7.5) vs. Jets, Rams (-7) vs. Ravens and Colts (-8.5) vs. Cardinals, who list Kyler Murray (foot) as questionable, though reports indicate he won’t play.
Browns vs. Steelers (-6), Chargers vs. Dolphins (+3.5) and Titans vs. Raiders (-3.5) are some other games with a line more than a field goal to consider for NFL survivor picks. Before finalizing any Week 6 NFL survivor picks, see which team the red-hot SportsLine Projection Model just went all-in on.
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The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 41-20 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns. The model can be used to crush the survivor pool format, which calls for picking one team to win each week but never using the same team twice.
Now, it has turned its attention to the latest Week 6 NFL schedule and locked in its Week 6 survivor pool pick. You can only see who the model is backing this week at SportsLine.
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Top Week 6 NFL survivor pool predictions
In Week 6 of the 2025 NFL season, the model is shying away from the Los Angeles Chargers as they take on the Miami Dolphins. The Chargers are 3.5-point and -202 money-line favorites, as one of the road favorites in the Week 6 lines, but are coming off a 27-10 home loss to the Washington Commanders. Justin Herbert has thrown four interceptions over his last three games after having three picks all of last season. The Dolphins, meanwhile, are off to a 1-4 start following a 27-24 loss at Carolina, and are in desperation mode if they are to still contend for a postseason berth.
Fading the Chargers may also be part of a greater NFL survivor pool strategy, which sees the Chargers play a struggling Titans team in a couple of weeks. The model projects the Chargers to win 57% of the time, which is lower than most other teams this week, making Los Angeles a team to avoid in NFL survivor pool picks. See which team to pick instead here.
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How to make Week 6 NFL survivor pool picks
Instead, the model is confidently backing a team many have not used in survivor pools to win outright in nearly 80% of simulations. The time to pick this team is now, and you can only see the play over at SportsLine.
Which surprising team is a must-back in your Week 6 NFL survivor pool? Visit SportsLine now to see which team carries you to victory in Week 6, all from the advanced computer model that nails survivor picks and is up well over $7,000 since its inception.
